Ethanone, 2,2,2-trifluoro-1-(1H-indol-3-yl)-
3-(Trifluoroacetyl)indole
CAS: 14618-45-2
Molecular Formula: C10H6F3NO
Ethanone, 2,2,2-trifluoro-1-(1H-indol-3-yl)- - Names and Identifiers
| Name | 3-(Trifluoroacetyl)indole |
| Synonyms | 3-(Trifluoroacetyl)indole 3-(TRIFLUOROACETYL)INDOLE 3-Indolyl trifluoromethyl ketone Ethanone, 2,2,2-trifluoro-1-(1H-indol-3-yl)- 2,2,2-TRIFLUORO-1-(1H-INDOL-3-YL)-1-ETHANONE |
| CAS | 14618-45-2 |
| InChI | InChI=1/C10H6F3NO/c11-10(12,13)9(15)7-5-14-8-4-2-1-3-6(7)8/h1-5,14H |
Ethanone, 2,2,2-trifluoro-1-(1H-indol-3-yl)- - Physico-chemical Properties
| Molecular Formula | C10H6F3NO |
| Molar Mass | 213.16 |
| Density | 1.423±0.06 g/cm3(Predicted) |
| Melting Point | 211-214°C(lit.) |
| Boling Point | 308.6±37.0 °C(Predicted) |
| Flash Point | 140.4°C |
| Vapor Presure | 0.000675mmHg at 25°C |
| Appearance | Solid |
| Color | White to Almost white |
| pKa | 14.31±0.30(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.568 |
| MDL | MFCD00182114 |
Ethanone, 2,2,2-trifluoro-1-(1H-indol-3-yl)- - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| Hazard Class | IRRITANT |
Ethanone, 2,2,2-trifluoro-1-(1H-indol-3-yl)- - Introduction
3-(Trifluoroacetyl)indole is an organic compound with the chemical formula C11H6F3NO. The following is a description of its nature, use, preparation and safety information:
Nature:
-Appearance: 3-(Trifluoroacetyl)indole is a white to light yellow solid.
-Solubility: It is soluble in organic solvents such as chloroform, dimethyl sulfoxide and dimethylformamide.
-Melting point: Its melting point is about 110-113 degrees Celsius.
Use:
- 3-(Trifluoroacetyl)indole is an important organic synthesis intermediate that can be used to synthesize various other compounds, such as pharmaceutically active molecules and pesticides.
-It can also be used as a synthetic precursor for dyes, catalysts and optical materials.
Method:
- 3-(Trifluoroacetyl)indole can be obtained by reacting indole with Trifluoroacetyl chloride. A specific step is to react the indole with trifluoroacetyl chloride in a suitable solvent, usually at low temperature, and using a suitable catalyst.
Safety Information:
- 3-(Trifluoroacetyl)indole has limited toxicity and hazard data and should be used in accordance with regular laboratory practices.
-Pay attention to prevent it from contacting with oxygen during handling and storage to avoid fire or explosion.
-Wear personal protective equipment such as glasses and gloves when conducting experiments.
-Detailed safety information should refer to the safety data sheet of the compound.
Nature:
-Appearance: 3-(Trifluoroacetyl)indole is a white to light yellow solid.
-Solubility: It is soluble in organic solvents such as chloroform, dimethyl sulfoxide and dimethylformamide.
-Melting point: Its melting point is about 110-113 degrees Celsius.
Use:
- 3-(Trifluoroacetyl)indole is an important organic synthesis intermediate that can be used to synthesize various other compounds, such as pharmaceutically active molecules and pesticides.
-It can also be used as a synthetic precursor for dyes, catalysts and optical materials.
Method:
- 3-(Trifluoroacetyl)indole can be obtained by reacting indole with Trifluoroacetyl chloride. A specific step is to react the indole with trifluoroacetyl chloride in a suitable solvent, usually at low temperature, and using a suitable catalyst.
Safety Information:
- 3-(Trifluoroacetyl)indole has limited toxicity and hazard data and should be used in accordance with regular laboratory practices.
-Pay attention to prevent it from contacting with oxygen during handling and storage to avoid fire or explosion.
-Wear personal protective equipment such as glasses and gloves when conducting experiments.
-Detailed safety information should refer to the safety data sheet of the compound.
Last Update：2024-04-09 02:00:42
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CAS: 14618-45-2
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